Fluorocitrate inhibition of aconitase: relative configuration of inhibitory isomer by x-ray crystallography.
نویسندگان
چکیده
The fluorocitrate isomer that is a strong inhibitor and inactivator of aconitase has been shown by x-ray crystallographic studies on the rubidium ammonium salt to have the configurations (1R : 2R) or (1S : 2S) 1-fluoro-2-hydroxy-1,2,3-propanetricarboxylic acid. A possible mechanism for the action of fluorocitrate is proposed which involves the 1R : 2R isomer suggested from biochemical data.
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ورودعنوان ژورنال:
- Science
دوره 170 3965 شماره
صفحات -
تاریخ انتشار 1970